High Sensitive Troponin T (hsTnT) and Copeptin as Prognostic Parameters in Patients With Elective Total Endoprosthesis

• Conditions: Perioperative Myocardial Infarctions; Pulmonary Embolism

• Registration Number: NCT01335815
• Lead Sponsor: Heidelberg University

Brief Summary

Summary: The purpose of the study is to prove if the biomarker high sensitive troponin T (hsTnT) and the biomarker of endogenous stress copeptin can serve as surrogate parameter of prognosis in patients with elective knee and hip total endoprosthesis.

Detailed Description

Consecutively, high sensitive troponin T and copeptin will be measured in all patients with elective knee and hip endoprosthesis in the orthopedic department of the University of Heidelberg. The blood is taken during the routine blood testes if possible, on admission and the days 1-4 following the operation. Usual baseline characteristics are taken as well as usual blood results (hb, cholesterol and so on). Primary endpoint is the detection of perioperative myocardial infarction and pulmonary embolism.

Study Timeline

• Study Start: 2011-03
• Status Verified: 2011-04
• Study First Submitted: 2011-04-13
• Study First Submitted QC: 2011-04-13
• Last Update Submitted: 2011-04-13
• Study First Posted: 2011-04-14
• Last Update Posted: 2011-04-14
• Primary Completion: 2012-03
• Study Completion: 2013-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Consecutive patients with elective knee and hip endoprosthesis

Exclusion Criteria

• Not willing or not able to take part in the observational trial
• No written inform consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of perioperative myocardial infarction and pulmonary embolism	Until 96h after operation

Trial Locations

Locations (1)

University of Heidelberg; 🇩🇪 Heidelberg, Baden-Württemberg, Germany