NCT02868255已完成不适用
Myeloid Derived Suppressor Cells Control by SIRP-alpha: Investigation in Hepatocellular Carcinoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- evaluation of the SIRP/CD47 expression
研究概览
简要总结
project is to study and develop anti-Signal Regulatory Protein α (SIRPα) antibodies (Ab) as a new immunotherapy strategy in cancer.
Samples harvested from hepatocellular carcinoma (HCC) and ovarian cancer patients will be used in evaluation of the SIRP-CD47 expression and of the effect of the anti-human Signal Regulatory Protein (hSIRP) Ab on various cellular types from patients and healthy volunteers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HCC patients (all BCLC stages accepted)
- •patient consent for the use of their biological samples
排除标准
- •patient with other cancers
- •hepatitis C or B positive
- •HCC treatment by chemo-embolization under 3 months
- •under Sorafenib treatment within the month prior to collection
- •underage or under guardianship patients
结局指标
主要结局
evaluation of the SIRP/CD47 expression
时间窗: baseline
samples harvested from HCC and ovarian cancer patients will be used in evaluation of the SIRP-CD47 expression and of the effect of the anti-hSIRP Ab on various cellular types from patients
次要结局
未报告次要终点
研究者
研究点 (1)
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