NL-OMON52795招募中不适用
Mapping the peritoneal immune system to identify novel immunomodulatory treatment options for diseases with peritoneal involvement. - MAPS
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 180
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Both males and females will be included in this study. To minimize the
- •potential risk of age and gender differences in the peritoneal immune system,
- •we will age and gender-match the samples for analyses from the control groups
- •and the peritoneal metastases group.
- •Patients are eligible when aged >18 old.
排除标准
- •The following general criteria will lead to exclusion from participation in
- •this study:
- •a. No informed consent is provided by patient or its legal representative
- •b. Signs of bleeding in the peritoneal cavity, as this will lead to
- •contamination of blood immune cells in the peritoneal cavity
- •c. Presence of intra-abdominal medical devices or corpus aliena, as this could
- •elicit a local inflammatory response
- •d. History of active peritoneal dialysis (CAPD)
- •e. Recent history (<1 year) of, or active episode of peritonitis
- •f. History of cisplatin or oxalitplatin use. These patients will be excluded as
- •it can hamper the analyses of samples for CyTOF.
- •Specific exclusion criteria per group:
- •Group 1: controls in which peritoneal involvement of disease is not to be
- •a. Patients will be excluded is there are signs of inflammation such as
- •increased CRP or leukocytosis.
- •b. Per-operative signs of inflammation in the peritoneal cavity such as
- •adhesions, cholecystitis (in the cholecystectomy group).
- •Group 2-6: patients with cancer with/without peritoneal metastases
- •a. Perforation of the gastrointestinal tract
研究者
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