Prediction Model of Response for Combined Chemo-Radio-therapy Based on Clinical and Molecular Biology
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Prediction model for CCRT response based on clinical and genetic molecular factors
研究概览
简要总结
- Retrospective review of old patients
- Analysis of prediction factors for concomitant chemo-radiotherapy in locally advanced and advanced esophageal cancer from 2005 to 2015
- Prospective case-control study: RNA sequencing & miRNA microarray
-
naive esophageal cancer patients who have a plan to receive concomitant chemo-radiotherapy
-
acquirement of tissue, blood, clinical information
-
isolation of RNA, DNA, serum database of clinical & demographic information
***Analysis of mRNA sequencing / miRNA sequencing**** first analysis of RNA sequencing: bioinformatician second analysis of RNA sequencing: principle investigator 3. Experimental set for qPCR (esophageal tissue) study group 4. TMA for screened exon gene 5. validation set for qPCR (esophageal tissue) 6. follow-up of circulating miRNA in blood (baseline blood & post-CCRT blood 3M, 6M, 12M) 7. Prediction model for CCRT response in esophageal Cancer based on clinical and molecular factors 8. Validate the prediction model.
详细描述
- Retrospective review of old patients
- Analysis of prediction factors for concomitant chemo-radiotherapy in locally advanced and advanced esophageal cancer from 2005 to 2015
Study Group
- non responder
- CR but recurrence
- CR and survival loner than 2 years
- Prospective case-control study: RNA sequencing & miRNA microarray
- naive esophageal cancer patients who have a plan to receive concomitant chemo-radiotherapy --> acquirement of tissue, blood, clinical information --> isolation of RNA, DNA, serum database of clinical & demographic information
study group
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •locally advanced or advanced esophageal cancer who want concomitant chemoradiotherapy
- •persons who assigned the written informed consents.
排除标准
- •persons who did't assign the informed consents
- •other organ cancer
- •heavy alcoholics
结局指标
主要结局
Prediction model for CCRT response based on clinical and genetic molecular factors
时间窗: up to 36 months
prediction model for CCRT response based on clinical and genetic molecular factors in esophageal cancer
次要结局
- banking of remained human material for post genetic & molecular study(up to 10 years)
- tissue prediction marker for CCRT response and prognosis(up to 5 years)
- circulating preditction marker for CCRT response and prognosis(up to 5 years)
- in-vitro prediction of CCRT using primary esophageal cancer organoid(up to 6 month)
研究者
Su Youn Nam
Professor
Kyungpook National University Hospital