Skeletal Muscle Perfusion With LVAD
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Skeletal muscle perfusion on contrast enhanced ultrasound
研究概览
简要总结
Advanced heart failure (when the heart pump fails) is associated with symptoms such as shortness of breath and extreme fatigue. Some of these symptoms are simply due to failure of the pump, however abnormal regulation of blood flow to the muscles of the body is also a potential mechanism. Left ventricular assist devices are mechanical pumps used to compensate for patients with failing hearts either as a bridge to heart transplant or as long term therapy. Whether or not these pumps improve muscle flow and whether this is a determinant in the improvement of symptoms is unknown. Understanding how skeletal muscle and heart perfusion is altered in heart failure patients before and after implantation of an LVAD could provide further insight into the beneficial effects of this therapy.
Specific Aims:
- To evaluate skeletal muscle and heart perfusion studies before and after LVAD implantation
- To compare functional status with degree of skeletal muscle perfusion.
详细描述
Methods:
Thirty patients deemed to be candidates for LVAD from either outpatient heart failure clinic or inpatient cardiology service will be studies. Skeletal muscle perfusion imaging using standard of care ultrasound technology will be performed prior to LVAD implant and then 3 months post implant. Functional status by six minute walk test and specialized stress test will be assessed at 3 months post implant.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients deemed to be candidates for a LVAD
排除标准
- •severe peripheral artery disease
- •skeletal muscle disorder
- •severe congenital heart disease
- •pregnancy
- •patients <18 yo
结局指标
主要结局
Skeletal muscle perfusion on contrast enhanced ultrasound
时间窗: 3 months
Skeletal muscle perfusion will be quantified: 1. Prior to LVAD placement 2. 3 months post LVAD placement
次要结局
- 6 minute walk test(3 month)
研究者
Jonathan R. Lindner, MD
Professor of Medicine
Oregon Health and Science University