Optical Angiography in Glaucoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 1
- 主要终点
- Retinal vessel diameter as extracted from the angiograms
研究概览
简要总结
Glaucoma is one of the leading causes for blindness in industrialized countries. It is characterized by a progressive loss of retinal ganglion cells, morphological changes in the optic nerve head and a characteristic loss of visual field. It has been speculated for a long time that vascular factors may also contribute to the pathogenesis of the disease. This concept has been supported by several epidemiological studies showing that small retinal vessel calibre are associated with the disease. In the recent years tremendous enhancements in the field of optical coherence tomography has been achieved. These developments made it possible to visualize the retinal vasculature in a full depth manner without the application of an intravenous marker. The proposed study tests the hypothesis that patients with glaucoma show altered vascular morphology compared to healthy subjects. This is of importance because it may clarify the degree of vascular involvement in glaucoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of manifest open angle glaucoma as defined as pathological optic disc appearance, glaucoma hemifield test outside normal limits and/or untreated IOP ≥ 21 mmHg on at least three measurements in the medical history. Mean deviation in the visual field test < 10dB
排除标准
- •Normal ophthalmic findings, IOP ≤ 20mmHg
- •No history of elevated IOP
- •No signs of glaucomatous disc damage
结局指标
主要结局
Retinal vessel diameter as extracted from the angiograms
时间窗: during the four weeks after the first screening day
次要结局
- Intraocular pressure(during the four weeks after the first screening day)
- Systemic hemodynamics (Blood pressure)(during the four weeks after the first screening day)
- pulse(during the four weeks after the first screening day)
研究者
Gerhard Garhofer
Assoc. Prof. PD Dr.
Medical University of Vienna