Blood Flow Regulation in Glaucoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Optic nerve head blood flow
研究概览
简要总结
Glaucoma is one of the leading causes for blindness in industrialized countries. It is characterized by a progressive loss of retinal ganglion cells, morphological changes in the optic nerve head and a characteristic loss of visual field. Although increased intraocular pressure has been identified as the major risk factor for the development and the progression of the disease it has been speculated for a long time that impaired ocular blood flow may contribute to the pathogenesis of the disease. This concept has been supported by several epidemiological studies showing that low ocular perfusion pressure and small retinal vessel caliber are associated with the disease.
The proposed study tests the hypothesis that patients with glaucoma have reduced total retinal blood flow as compared to healthy subjects. Additionally, autoregulation of blood flow will be investigated during an increase in ocular perfusion pressure. This is of importance because it may clarify the degree of vascular involvement in glaucoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with open angle glaucoma:
- •Diagnosis of manifest open angle glaucoma as defined as pathological optic disc appearance, glaucoma hemifield test outside normal limits and/or untreated intraocular pressure ≥ 21 mmHg on at least three measurements in the medical history. Mean deviation in the visual field test < 10 decibel
- •Healthy control subjects:
- •normal ophthalmic findings and intraocular pressure < 20 mmHg on at least three measurements
- •no evidence of increased intraocular pressure in the medical history
- •no signs of glaucomatous damage in the optic disc or the glaucoma hemifield test
排除标准
- •Presence or history of a severe medical condition as judged by the investigator
- •Abuse of alcoholic beverages
- •Participation in a clinical trial in the 3 weeks preceding the study
- •Exfoliation glaucoma
- •Pigmentary glaucoma
- •Secondary glaucoma
- •Ocular hypertension
- •History of acute angle closure
- •Intraocular surgery within the last 6 months
- •History of epilepsia
- •Diabetes mellitus
- •Ocular inflammation or infection within the last 3 months
- •Untreated hypertension with systolic blood pressure >160 mmHg, diastolic blood pressure >95 mmHg
- •Pregnancy or lactating
结局指标
主要结局
Optic nerve head blood flow
时间窗: once
次要结局
- Retinal blood flow(once)
研究者
Gerhard Garhofer
Assoc. Prof. Univ. Doz. Dr.
Medical University of Vienna