Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Patients With Normal Tension Glaucoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mean Blur Ratio
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Change in mean blur rate
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Glaucoma is the second leading cause of blindness worldwide. Literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma. It has been shown that flicker light-induced vasodilatation of retinal veins is diminished in patients with glaucoma. Also previous studies indicate that the blood flow autoregulation is impaired in patients with glaucoma. Therefor the ocular perfusion pressure can not be maintained stable during changes of the systemic arterial blood pressure. Laser speckle flowgraphy (LSFG) represents a non-invasive method to quantify ocular perfusion also at the ONH. LSFG enables noninvasive quantification of microcirculation of the optic disc in Japanese glaucoma patients.
Study Objectives:
To assess the changes in LSFG parameters in patients with normal tension glaucoma, compared to healthy subjects during flicker light stimulation and isometric exercises.
Investigators
Matthias Bolz
Prof.
Augenabteilung Allgemeines Krankenhaus Linz
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •a) Study population: patients with normal tension glaucoma
- •History of ocular or systemic disease causing optic nerve damage
- •History of IOP greater than 21 mm Hg (corrected by CCT)
- •Participation in a clinical trial in the 3 weeks preceding the study
- •Ocular surgery (including intravitreal injection) during the 3 months preceding the study
- •Ametropia \> 6 Dpt
- •pre- or perimenopausal women
- •Relevant ophthalmic diseases/conditions that could interfere with LSFG measurements (e.g. optic nerve head drusen, tilted disc, etc.)
- •Opacities of the cornea (e.g. corneal scars, corneal oedema), the lens (e.g. LOCS-II grading \> 2, posterior capsule opacification) or the vitreous (e.g. vitreous haemorrhage, asteroid hyalosis)
- •Patients who are not able to cooperate or with insufficient ability to fixate (tremor, nystagmus)
Outcomes
Primary Outcomes
Change in mean blur rate
Time Frame: 5 minutes