Optical Angiography in Glaucoma

Completed

• Conditions: Glaucoma
• Interventions: Device: Optical angiography based on OCT

• Registration Number: NCT02548676
• Lead Sponsor: Medical University of Vienna

Brief Summary

Glaucoma is one of the leading causes for blindness in industrialized countries. It is characterized by a progressive loss of retinal ganglion cells, morphological changes in the optic nerve head and a characteristic loss of visual field. It has been speculated for a long time that vascular factors may also contribute to the pathogenesis of the disease. This concept has been supported by several epidemiological studies showing that small retinal vessel calibre are associated with the disease. In the recent years tremendous enhancements in the field of optical coherence tomography has been achieved. These developments made it possible to visualize the retinal vasculature in a full depth manner without the application of an intravenous marker. The proposed study tests the hypothesis that patients with glaucoma show altered vascular morphology compared to healthy subjects. This is of importance because it may clarify the degree of vascular involvement in glaucoma.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-09-04
• Study First Submitted QC: 2015-09-10
• Study Start: 2015-09-11
• Study First Posted: 2015-09-14
• Primary Completion: 2016-11
• Study Completion: 2016-11-25
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-06
• Last Update Posted: 2022-04-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

• Diagnosis of manifest open angle glaucoma as defined as pathological optic disc appearance, glaucoma hemifield test outside normal limits and/or untreated IOP ≥ 21 mmHg on at least three measurements in the medical history. Mean deviation in the visual field test < 10dB

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Exclusion Criteria

• Normal ophthalmic findings, IOP ≤ 20mmHg
• No history of elevated IOP
• No signs of glaucomatous disc damage

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Glaucoma Patients	Optical angiography based on OCT	Patients with primary open angle glaucoma
Healthy controls	Optical angiography based on OCT	age- and sex matched controls

Primary Outcome Measures

Name	Time	Method
Retinal vessel diameter as extracted from the angiograms	during the four weeks after the first screening day

Secondary Outcome Measures

Name	Time	Method
Systemic hemodynamics (Blood pressure)	during the four weeks after the first screening day
Intraocular pressure	during the four weeks after the first screening day
pulse	during the four weeks after the first screening day

Trial Locations

Locations (1)

Medical University of Vienna; 🇦🇹 Vienna, Austria