ISRCTN27860457已完成未知
ON-EPIC Oral nitrate supplementation to enhance pulmonary rehabilitation in chronic obstructive pulmonary disease: a multi-centre, double blind, placebo-controlled, cross-over study
Imperial College, London (UK)0 个研究点目标入组 165 人开始时间: 2014年10月29日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 165
研究概览
简要总结
2020 results in https://pubmed.ncbi.nlm.nih.gov/32376732/ (added 19/11/2020)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Patients will need to have a clinical and spirometric diagnosis of COPD, GOLD stage II-IV and with an MRC score of 3-5 or to be functionally limited
排除标准
- •1. Clinically unstable patients (within one month of exacerbation)
- •2. Within one month of completing pulmonary rehabilitation
- •3. Significant comorbidity limiting exercise tolerance
- •4. Significant renal impairment (estimated glomerular filtration rate (eGFR) <50 ml.min-1)
- •5. Hypotension (systolic blood pressure <100 mmHg)
- •6. Pregnancy
- •7. Use of nitrate based medication
- •8. Other reason for benefit from nitrate supplementation (ischaemic heart disease, peripheral arterial disease)
- •9. Use of long-term oxygen therapy
研究者
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