Regular Consumption of High Phytate Diet Reduces Inhibitory Effect of Phytate on Nonheme Iron Absorption in Female Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 主要终点
- Area under the curve for serum iron for assessing bioavailability
研究概览
简要总结
The purpose of this study is to investigate whether regular consumption of phytate dampens its negative effect on nonheme iron absorption.
详细描述
Phytate is one of the main inhibitors of nonheme iron absorption. High phytate consumption is of concern in developing countries because of the high prevalence of iron and zinc deficiency in these countries. In this study, we investigated the effect of habitual consumption of a high phytate diet on the inhibitory effect of phytate on nonheme iron absorption. Thirty-two non-anemic female subjects with ferritin ≤ 30µg/L were randomized into two groups, after matching for ferritin concentration. Each group consumed either high or low phytate foods that were provided for 8 wk. Iron bioavailability from a high phytate test meal was measured using area under the curve (AUC) for serum iron at baseline and after the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Marginal iron status (Serum ferritin <30ug/L)
- •BMI in the range 18.5-24.9kg/m2
- •Willing to modify diet to increase or decrease phytate intake
- •Willing to give multiple blood samples at beginning and end of study
排除标准
- •Lactating
- •Anemic (hemoglobin <120 g/L)
- •Has gastro-intestinal disease/condition that can affect absorption
研究组 & 干预措施
High Phytate Diet
The high phytate diet group was required to consume a high phytate diet for 8 weeks. The high phytate foods were provided for subjects. They received whole grain ready-to-eat cereals, whole wheat pasta/spaghetti, tortillas, bagels, bread and dinner rolls, corn tortillas, brown rice, canned black beans, edamame and tofu, and were encouraged to consume generous amounts of nuts and other legume products high in phytate.
干预措施: High phytate intake (Other)
Low Phytate Diet
The low phytate diet group was required to consume a low phytate diet for 8 weeks. They received foods similar to those for the high phytate diet group but which were made from refined wheat and white rice, eggs and cheese, and were instructed to avoid high phytate foods.
干预措施: Low phytate intake (Other)
结局指标
主要结局
Area under the curve for serum iron for assessing bioavailability
时间窗: 8 weeks
次要结局
未报告次要终点
研究者
Dr. Manju B. Reddy
Professor
Iowa State University