Oocyte vitrification in women at risk of ovarian failure; an observational study with follow-up of children - Oocyte vitrification

Academisch Medisch Centrum0 个研究点目标入组 190 人开始时间: 待定最近更新: 2024年5月6日

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•Oocyte vitrification will be offered to women at risk of ovarian failure due to iatrogenic gonadotoxic treatment or due to increasing age, as well as to women undergoing IVF/ICSI in whom unexpectedly no spermatozoa can be obtained at the time of follicle aspiration.;Inclusion criteria;1. Women between the age of 16 and 40 years who are at risk of ovarian failure due to iatrogenic gonadotoxic treatment (cancer treatment);2. Women between the age of 30 and 40 years who are at risk of ovarian failure due to increasing age. ;3. Women between the age of 18 and 42 years undergoing IVF/ICSI during which no
•spermatozoa can be obtained at the time of follicle aspiration.

•1. Women with borderline or invasive ovarian cancer.
•2. Women with contraindications for IVF treatment such as cardiovascular-pulmonary disease, severe diabetes, bleeding disorders, immunodeficiency, morbid obesity, and premature ovarian failure.
•3. Women with severe psychopathology, severe anxiety and inability to cope.
•4. Women who are, at the time of the requested thawing of their oocytes, above the age at which embryo transfer is considered safe: currently 45 years of age (modelreglement embryowet 2003)
•5. Not able or willing to provide informed consent.

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