The Efficacy of Early Screening and Treatment of Depression with Selective Serotonin Reuptake Inhibitor (SSRI) in Adult Glioma Patient

Asan Medical Center0 个研究点目标入组 112 人开始时间: 待定最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•1)Understand and voluntarily sign an informed consent document prior to any study related assessment/procedures are conducted
•2)First time histologically confirmed diagnosis of glioma (resection or biopsy)
•3)Age =18 years and = 85 years
•4)Glasgow Coma Score (GCS) 5-15

•1)Unable to perform the screening test due to the neurologic deficit
•2)Evidence of ongoing acute brain bleeding on CT or MRI
•3)Previously confirmed diagnosis of a benign, low- or high-grade brain tumor
•4)Diagnosis of systemic cancer other than glioma (breast cancer, lung cancer, gastric cancer, colon cancer etc.)
•5)Currently taking antidepressant drugs
•6)Previously suffered from depression in the past or within 5 years of diagnosis, and currently do not receive drug therapy
•7)Taking following drugs: MAO (monoamine oxidase) inhibitor, linezolid, thioridazine, mesoridazine, pimozide, tizanidine, terfenadine, astemizole or cisapride
•8)SSRI allergic history
•9)On antiplatelets or anticoagulation agents (aspirin, clopidogrel, cilostazol, heparin, warfarin ?vitamin K antagonist?, DOAC ?Direct Oral Anticoagulants?)
•10)On non-steroidal anti-inflammatory drug (NSAID)
•11)High bleeding risk patients: hematologic disorder, thrombocytopenia ( < 50, 000/µL), coagulopathy
•12)History of coronary artery disease or gastrointestinal (GI) bleeding
•13)Post-anoxic coma; status epilepticus; Parkinson; central nervous system (CNS) infections (community-acquired; hospital-acquired; ventriculitis; post-operative)
•14)Pregnancy or breastfeeding patient
•15)Life expectancy less than 3 month
•16)DNR (do not resuscitate) ordered patient

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