The Effect of Supervised Aerobic Exercise on Adipokine and Myokine Biomarkers in Patients With Cancer During Systemic Chemotherapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Irisin
研究概览
简要总结
This study is a single-blinded, prospective, controlled trial aiming to evaluate the effect of supervised aerobic exercise on adipokine and myokine biomarkers in patients with breast or colon cancer during their systemic chemotherapy.
详细描述
To determine the effect of aerobic exercise on adipokine and myokine biomarkers such as Interleukin-6 (IL-6), Irisin, Leptin and Adiponectin in the blood of breast or colon cancer patients receiving chemotherapy compared to ones who did not exercise during their systemic chemotherapy.
Patients who were diagnosed with solid type of cancer specifically focusing on breast or colon cancer will be recruited either to the exercise group (EG) or control group (CG) during their systemic chemotherapy. An individualized supervised resistive aerobic exercise which will be performed via stationary resistive biycle ergometer will be implemented along with the chemotherapy process for EG.
Each exercise session will be performed 2 times per week for at least 12 weeks (can be extended up to 24 weeks) during chemotherapy.
Exercise intensity will be set as submaximal, 50-70% of heart rate reserve, and each session will be lasted 35 minutes.
All exercise sessions will be supervised by the researchers to avoid potential side effects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having been diagnosed with solid type of cancer
- •Being candidate for systemic chemotherapy
- •Being volunteer to participate in an exercise program
- •Aged between 18-70 years old
排除标准
- •Having 2 or above grades according to the Eastern Cooperative Oncology Group (ECOG) performance status
- •Having mental and/or cognitive deficits
- •Ongoing medical and/or surgical (if any) complications
- •Having neurological/orthopedical and/or severe respiratory dysfunctions
- •Having any condition which corresponds to the contraindication of exercise (i.e. advanced stages, distant metastasis, infection)
- •Having unstable vital parameters or having regularly used pharmacological interventions
结局指标
主要结局
Irisin
时间窗: From completion of systemic chemotherapy up to one week
Measuring Serum levels of Irisin via ELISA
Adiponectin
时间窗: From completion of systemic chemotherapy up to one week
Measuring Serum levels of Adiponectin via ELISA
Leptin
时间窗: From completion of systemic chemotherapy up to one week
Measuring Serum levels of Leptin via ELISA
Interleukin-6 (IL-6)
时间窗: From completion of systemic chemotherapy up to one week
Measuring Serum levels of IL-6 via ELISA
次要结局
未报告次要终点
研究者
Alper Tuğral
Project Coordinator
Izmir Bakircay University