Pituitary dysfunction after traumatic brain injury: a new challenge in neurotraumatology - Pituitary dysfunction after traumatic brain injury

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 600 人开始时间: 待定最近更新: 2024年5月13日

适应症

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•1. All patients who visit the emergency department with a mild, a moderate or a severe traumatic brain injury. (Mild traumatic brain injury is defined as a history of impact to the head and a Glasgow Coma Scale score (GCS) 13-15 at entry in the emergency room, moderate traumatic brain injury is defined as a GCS 9-12 at entry in the emergency room, and severe traumatic brain injury is defined as a GCS <= 8 at entry in the emergency room)
•2. Initial trauma occurred less than 24 hours before visiting the Emergency Department.
•3. Age >= 18 years and <= 65 years

•1. Age > 65 years or < 18 years
•2. No oral or written informed consent by patient or proxy
•3. Pre-existent neuro-endocrine disorder
•4. Instable infiltrative disease in the hypothalamus/pituitary region (eg sarcoidosis, tumour metastasis)
•5. BMI >30 kg/m2
•6. Pregnancy or wish for pregnancy during the study period women, lactation
•7. Co-existent disease with decreased life expectancy, especially active malignant tumor
•8. Chronic alcohol or drug abuse

发起方

niversitair Medisch Centrum Sint Radboud