Study of the Representation of Action Peripersonal Space in Participants With Unilateral Segmental Exclusion of the Upper Limb Compared to Asymptomatic Subjects
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Judgment Error of Reachability
研究概览
简要总结
This study aims to evaluate the representation of action peripersonal space (PPS) in subjects suffering from unilateral segmental exclusion syndrome of the upper limb compared to healthy control subjects. Segmental exclusion is defined by non-use or under-use of a limb segment without central nervous system damage. The study hypothesizes that this syndrome leads to a modification (shrinkage) of the PPS representation. Participants will perform reachability judgments in a Virtual Reality (VR) environment.
详细描述
Segmental exclusion syndrome often occurs after limb trauma and manifests as a neglect-like behavior of peripheral origin, sometimes associated with Complex Regional Pain Syndrome (CRPS). The study explores whether the lack of limb use affects the representation of peripersonal space (PPS)-the space immediately surrounding the body where interactions with objects occur.
The study is monocentric, observational, with a matched control group. Participants will undergo:
Clinical assessment (questionnaires on pain, anxiety, body perception, and kinesiophobia).
A Virtual Reality (VR) test (approx. 40 minutes). In VR, participants will judge whether a cylinder presented at different distances and angles is reachable without moving (Perceived Reachable Distance - DMA-p). This will be compared to their Real Reachable Distance (DMA-r).
The goal is to measure the error of judgment to assess PPS representation and check for correlations with body schema disturbances or functional impairment
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •(patients):
- •Age ≥ 18 years.
- •Presenting unilateral exclusion symptom of the upper limb or part of the hand evolving for > 3 months.
- •No contraindication to force work in daily activities.
- •For patients with finger exclusion: at least 2 perturbed items related to exclusion on tests 3 and 4 of the "Bilan 400 points".
- •Affiliated to a social security scheme.
- •Able to understand simple orders.
- •Inclusion Criteria (Controls):
- •Age ≥ 18 years.
- •No history of upper limb impairment with sequelae.
排除标准
- •Visual impairments.
- •Central neurological pathology.
- •Unstabilized psychiatric pathology.
- •Communication or comprehension difficulties.
- •Under legal protection or unable to consent.
- •Pregnant or breastfeeding women.
- •Cervical pathology contraindicating VR headset use.
- •Epilepsy.
- •Upper limb pathology unrelated to exclusion.
- •Inability to stand for 40 minutes.
研究组 & 干预措施
Patients with Exclusion
Patients presenting with unilateral segmental exclusion of the upper limb or part of the hand evolving for more than 3 months.
干预措施: Reachability Judgment Task in VR. (Behavioral)
Healthy Controls
symptomatic volunteers with no history of upper limb impairment with sequelae.
干预措施: Reachability Judgment Task in VR. (Behavioral)
结局指标
主要结局
Judgment Error of Reachability
时间窗: Day 1 (During the 40-minute VR assessment)
The Judgment Error of Reachability is a single composite metric calculated as: ((DMA-p - DMA-r) / DMA-r) × 100, expressed as a percentage (%). Both DMA-p (Perceived Maximum Reachable Distance) and DMA-r (Real Maximum Reachable Distance) are measured in centimeters, and their ratio yields a single dimensionless percentage score.
次要结局
- Body Perception Disturbance Score(Day 1 (Before VR task))
- Anxiety and Depression Score (HAD)(Day 1)
- Kinesiophobia Score (Tampa Scale)(Day 1)
- Pain Catastrophizing Score (PCS)(Day 1)
- Functional Impairment Score (400-Point Hand Assessment)(Day 1)