Role of combined therapy of Vitamin B-12 and Folic acid in cognition of elderly dementia patients in a tertiary care hospital in Eastern India.

This is a longitudinal observational study to be conducted in Psychiatry Outdoor and the Department of Pharmacology of R.G Kar Medical College where 40 patients will be recruited above age of 60years and had been showing forgetfulness in daily life activities. Their baseline dementia scores will be assessed using Addenbrooke’s cognitive examination scale and Blessed Dementia Scale during first time registration. After the baseline cognitive assessment, combined therapy with Vitamin B-12 1.5mg and folic acid 5mg will be advised everyday for 6months. Next follow up will be done after 6months and the cognitive assessment  scores will be checked again. The same medicines will be advised again for 6months. Final follow up will be done after next 6months in the same way. Then it will be seen whether there is change in Cognitive assessment scores from baseline and first follow up to the final follow up , with the combined therapy of Vitamin B-12 1.5mg and Folic acid 5mg.

It is expected that there will be in improvement of cognition in these patients and it will improve their quality of life.