Intradialytic Acid-base Changes and Organic Anion Production With High Versus Low Bicarbonate Hemodialysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Pre-dialysis serum bicarbonate
研究概览
简要总结
This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens.
详细描述
This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens. These parameters will be assessed in patients currently receiving high-bicarbonate hemodialysis as part of usual care. They will then be switched to a lower bicarbonate prescription, after which these parameters will be reassessed. The study will also examine changes in inflammatory markers, glycemic control, ketogenesis, and lipolysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving chronic thrice-weekly conventional hemodialysis for at least 6 months
排除标准
- •Use of oral alkali within the previous month
- •Hospitalization within the previous month
- •Inability to provide written informed consent
- •Plans for kidney transplant in the next 2 months
- •Planned change in phosphate binder therapy within the next month
- •Pregnancy, or planned pregnancy in the next 2 months
研究组 & 干预措施
Low bicarbonate
Low bicarbonate hemodialysis - 30 mEq/L dialysate bicarbonate
干预措施: Low Bicarbonate (Other)
结局指标
主要结局
Pre-dialysis serum bicarbonate
时间窗: 5 weeks
Change in predialysis bicarbonate
次要结局
- interleukin-6(5 weeks)
- serum beta-hydroxybutyrate(5 weeks)
- beta-hydroxybutyrate clearance(5 weeks)
- Dialysis symptom questionnaire(5 weeks)
- serum free fatty acids(5 weeks)
- Time to recover from dialysis(5 weeks)
研究者
Matthew Abramowitz
Assistant Professor
Albert Einstein College of Medicine