Application in High Risk Groups of Recently Developed Noninvasive Methods in Diagnosing Coronary Heart Disease.A Community Based Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Prevalence of cardiac abnormalities/disease according to different examination modalities
研究概览
简要总结
The purpose of this study is to investigate the prevalence of cardiac disease/coronary artery disease and diagnostic yield of different non-invasive methods in patients with type 2 diabetes 40-75 years of age at examination. Exercise tests, Doppler echocardiographic examination with Tissue Velocity Imaging, stress Echocardiography, transthoracic Doppler of coronary arteries with coronary flow reserve, and cardiac MRI with late enhancement at rest, and perfusion after vasodilatation stress will be used in the study. A subpopulation will in addition measure forearm vasodilation(FMD) and CFR before and after 4 months of exercise training.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes
- •Age at diagnosis > 30 years
- •Age at inclusion 40-75 years
排除标准
- •Angina pectoris
- •Coronary angiography/stress-test diagnostic of coronary artery disease last 3 years
- •Previous myocardial infarction, coronary bypass operation/PCI or heart failure
- •Clinical indication for stress -testing
- •Active bronchospasm excluding use of adenosine
- •eGFR < 30 ml/min/m2
- •short estimated life expectancy due to cancer, chronic liver/renal diseases
结局指标
主要结局
Prevalence of cardiac abnormalities/disease according to different examination modalities
时间窗: at primary examination
次要结局
- Relationship between CFR in LAD and forearm FMD(4 months)
- Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI.(at baseline)
- Doppler echocardiographic findings related to clinical, laboratory and MRI findings(at baseline)
- Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI(4 months)