Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Persistence/resolution of dysfunctional breathing at follow-up visit
研究概览
简要总结
Dysfunctional breathing might participate to dyspnoea in long COVID-19. This study investigate the prognosis of patients diagnosed with dysfunctional breathing after SARS-CoV-2 infection in our center.
详细描述
Dysfunctional breathing (DB) with or without hyperventilation syndrome (HVS) as diagnosed using cardiopulmonary exercise test (CPET) was recently demonstrated as an important physiopathological mechanism of persistent dyspnoea in long COVID patients [1]. DB is characterized by specific ventilation pattern on CPET accompanied by respiratory discomfort and/or dyspnea at exercise [2]. Most patients with DB will have undergone some sort a specific physiotherapy retraining [3]. However the prognostic and the predictors of persistence/resolution of DB after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown.
The aim of the study is to determine the prognostic of patients diagnosed with DB after SARS-CoV-2 infection, as well as prognosis factors and predictors of persistence/resolution of DB during a prospective follow up visit.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 14 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients 14 years or more
- •diagnosis of DB after SARS-CoV-2 at our long covid clinic using a combined approach of symptoms and CPET analysis in the hospitals of Sion, Martigny or Rennaz
- •Inclusion between November 2020 and until the end of October 2021
排除标准
- •Refusal to participate
- •comorbidities preventing the CPET or PFT to be carried out
结局指标
主要结局
Persistence/resolution of dysfunctional breathing at follow-up visit
时间窗: 6 to 9 monts from diagnosis
defined by persistence/resolution of dyspnea, as compared with patient's baseline (equivalent level of dyspnea as before COVID-19).
次要结局
- Change in ETCO2 and PaCO2(6 to 9 monts from diagnosis)
- Score HADS changes(6 to 9 monts from diagnosis)
- Qualitative changes (increase/decrease/no change of DB pattern of CPET)(6 to 9 monts from diagnosis)
- Change in ventilatory patterns (tidal volume [VT], breathing frequency [BF] at isowork as compared with baseline(6 to 9 monts from diagnosis)
- Dispersion of VT and BF during the CPET(6 to 9 monts from diagnosis)
- Score SF-36 changes(6 to 9 monts from diagnosis)
- Specific symptom scale changes(6 to 9 monts from diagnosis)
- Specific work capacity changes questions(6 to 9 monts from diagnosis)
- Post-COVID Functional Status (PCFS) changes(6 to 9 monts from diagnosis)