Assessment of the Force Frequency Relationship of the Myocardium After On-pump CABG Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- End-systolic elastane of the left ventricle.
研究概览
简要总结
The aim of the study is to determine whether increasing the heart rate by epicardial atrial pacing after surgery improves the contractile force of the myocardium. After complete weaning from CPB, several pressure-loops of the LV will be recorded at different levels of preload using transoesophageal echo, invasive blood pressure monitoring. The preload will be manipulated by adding fluid from the CPB reservoir or draining fluid into the CPB reservoir.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CABG only surgery
- •Preopeartive LVEF ≥ 53 %
- •Use of epicardial pacing wires to assist CPB weaning
排除标准
- •Contra-indication to TEE
- •AV block at the time of CPB weaning
- •Sinus rhythm less than 50 or more than 90 BPM after CPB weaning.
研究组 & 干预措施
Spontaneous rhythm first
Stepwise preload increase by repeated administration of 100 mL of fluid during spontaneous rhythm and then stepwise preload reduction by repeated drainage of 100 mL of fluid during atrial pacing.
干预措施: External Pacing Box (Device)
Atrial pacing first
Stepwise preload increase by repeated administration of 100 mL of fluid during atrial pacing and then stepwise preload reduction by repeated drainage of 100 mL of fluid during spontaneous rhythm.
干预措施: External Pacing Box (Device)
结局指标
主要结局
End-systolic elastane of the left ventricle.
时间窗: 30 minutes after CPB weaning
次要结局
未报告次要终点
研究者
Jean François Brichant
Professor, Head of Department
University of Liege