ISRCTN70365169已完成未知
Computer Assisted Management of Early Rheumatoid Arthritis-II: Does prednisone inhibit progression of joint damage if early RA is treated very intensively with disease modifying antirheumatic drugs (DMARDs)?
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 220
研究概览
简要总结
- 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22393128 2. 2013 results in http://www.ncbi.nlm.nih.gov/pubmed/22807253 3. 2020 results in https://pubmed.ncbi.nlm.nih.gov/32907614/ (added 11/09/2020)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Rheumatoid Arthritis, defined according to the revised American College of Rheumatology (ACR) criteria for Rheumatoid Arthritis
- •2. A disease duration of less than 1 year, estimated by the rheumatologist
- •3. Age >18 years
- •4. No previous treatment with DMARDs or oral glucocorticoids
- •5. Written informed consent by the patient
排除标准
- •1. Abnormal renal function (Cockroft <75 ml/min)
- •2. Abnormal liver function (aspartate aminotransferase [ASAT]/alanine aminotransferase [ALAT] >2 x normal), active or recent hepatitis, cirrhosis
- •3. Major co-morbidities like malignancies, severe diabetic mellitus, severe infections, severe cardio and/or respiratory diseases
- •4. Leukopenia and/or thrombocytopenia
- •5. Inadequate birth control contraception, pregnancy, and/or breastfeeding
- •6. Treatment with cytoxic or immunosuppressive drugs within a period of 3 months prior to the study
- •7. Alcohol intake >2 units per day or drug abuse, presently or in the past
- •8. Psychiatric or mental disorders which makes adherence to the study protocol impossible
- •9. Taking part in another clinical trial
- •10. Osteoporotic vertebral fractures
研究者
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