CTRI/2022/09/045889招募中未知
Genetic profiling of women with infertility requiring assisted reproduction
试验速览
- 阶段
- 未知
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •1. Consenting female subjects aged between 21-35 years
- •2. Couples who have been trying to conceive for at least 1 year
- •3. Clinical diagnosis of unexplained infertility
- •4. Patients who have not conceived with 3 ART cycles (IUI or IVF) with donor gametes, if
- •partner is diagnosed with male factor infertility
- •5. Normal uterine cavity as visualised by 3-D ultrasound or hysteroscopy
- •6. At least one patent fallopian tube as evaluated by sonosalpingography or
- •hysterosalpingography or laparoscopy
排除标准
- •1. Body mass index (BMI) =30 kg/m2
- •2. History of known structural anomalies of the uterus or cervical stenosis as established by
- •clinical examination and diagnostic procedures such as hysteroscopy or laparoscopy or
- •3. History of ovarian factor infertility as established by a diagnosis of PCOS, ovarian cysts
- •or tumours on ultrasound
- •4. Clinical history of irregular menstrual cycles or amenorrhea
- •5. History suggestive of poor ovarian reserve with an antral follicle count (AFC) of =5 on
- •day 2 or Anti-Mullerian Hormone levels (AMH) of <1.2 ng/mL at the time of diagnosis
- •at initial clinical presentation
- •6. History suggestive of uncontrolled thyroid disorder, uncontrolled diabetes mellitus or
- •hyperprolactinemia or clinically significant changes in hormones that may be associated
- •with infertility
- •7. Any abnormalities detected on ultrasound or hysterosalpingography or laparoscopy or
- •hysteroscopy that may be associated with infertility
- •8. Any prior medical or surgical treatments in female partner that may be associated with
- •infertility
- •9. History or lab investigations suggesting presence of STIs (HIV1/2, HBsAg, HCV)
- •10. Clinical history of infectious disease or autoimmune disease known to cause infertility
- •eg. Genital Tuberculosis, SLE
- •11. History of any known chromosomal defects or genetic disorders in the subject
- •12. History of any pregnancy in the past in subjects
- •13. History of recurrent pregnancy loss or miscarriages in the subject
- •14. History of male factor infertility, if the couple has not tried at least 3 cycles of ART (IUI
- •or IVF) with donor sperms
- •15. Any psychosexual causes in the couple which may result in a failure to conceive, if the couple has not undergone an assisted reproductive technology (IUI and IVF) based
研究者
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