NCT04924985已完成不适用
Goal-Directed Cardiopulmonary Resuscitation in Cardiac Arrest Using a Novel Physiological Target
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 106
- 试验地点
- 2
- 主要终点
- Rate of Return of Spontaneous Circulation (ROSC)
研究概览
简要总结
The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological targets to predict survival and neurological outcome, the impact of physiological-feedback CPR will be assessed. 150 adult patients who have a cardiac arrest event at NYU Tisch Hospital will be randomized to one of two treatment groups: (1) Physiological-Feedback CPR or (2) Non-Physiological (Audiovisual) Feedback CPR.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •In-hospital cardiac arrest patient
- •Age ≥18 years
- •Age <80 years
- •CPR lasting ≥5 minutes
排除标准
- •Patients < 18 years of age or > 80 years of age
- •Out of hospital cardiac arrest patients
- •≥3 acute organ failures (defined as acute renal failure requiring dialysis, fulminant liver failure i.e. liver failure with INR≥1.5, respiratory failure requiring mechanical ventilation)
- •Repeat in-hospital cardiac arrest event within 14 days of a prior cardiac arrest
- •Presence of known raised intracranial pressure
- •Presence of known traumatic brain injury or subarachnoid hemorrhage <14 days old, frontal lobe brain tumors or subdural hemorrhage
- •Hyperbilirubinemia >1.0 mg/dl (based on the absorption of near-infrared light by bilirubin)
- •Resuscitation using extra-corporeal membrane oxygenation (ECMO)
研究组 & 干预措施
Non-Physiological (Audiovisual) Feedback CPR
Active Comparator
干预措施: Non-Physiological Feedback CPR (Other)
Physiological Feedback CPR
Experimental
干预措施: Physiological Feedback CPR (Other)
结局指标
主要结局
Rate of Return of Spontaneous Circulation (ROSC)
时间窗: Day 0
次要结局
- Release of Lactate(Day 0)
- Release of interleukin (IL)-6(Day 0)
- Cerebral Performance Category (CPC) Score(Day 30)
- Change in mean rSO2 during CPR as markers of the quality of resuscitation(Day 0)
- Change in mean ETCO2 during CPR as markers of the quality of resuscitation(Day 0)
研究者
研究点 (2)
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