NCT04496570已完成不适用
The Role of Resolvin D1 in Maintaining Oral Health
Ordu University2 个研究点 分布在 2 个国家目标入组 26 人开始时间: 2019年7月31日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Biochemical parameter (resolvin D1)
研究概览
简要总结
The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.
A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Stage 3, Grade B and generalized periodontitis patients
排除标准
- •excessive forces;
- •presence of systemic diseases
- •administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
- •having received non-surgical periodontal treatment within the past 6 months
- •allergy or sensitivity to any drug,
- •pregnancy, lactation
- •current and former use of tobacco.
结局指标
主要结局
Biochemical parameter (resolvin D1)
时间窗: Baseline and 1 month after NSPT
The changes in levels of resolvin D1 after periodontal treatment determined by ELISA.
次要结局
- Clinical attachment level (CAL)(Baseline and 1 month after NSPT)
- Gingival index (GI)(Baseline and 1 month after NSPT)
- Probing pocket depth(Baseline and 1 month after NSPT)
- Plaque index (PI)(Baseline and 1 month after NSPT)
研究者
Ceren Gökmenoğlu
Principal investigator
Ordu University
研究点 (2)
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