Study of the Association Between Subtypes of Anti Citrullinated Peptide Antibodies and Lung Damage in Rheumatoid Arthritis in the West Indies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 77
- 试验地点
- 1
- 主要终点
- Frequency of the positivity of the anti citrullinated peptide antibodies and subtype
研究概览
简要总结
Rheumatoid arthritis is a genuine systemic disease associated with diffuse interstitial pneumopathy and bronchial disorders. According to the literature review, the prevalence of PID on thoracic CT scan is one-third of patients. Diffuse interstitial pneumopathy is responsible for a significant morbidity and mortality, is currently under-diagnosed and its treatment is poorly codified. The lung seems to have a central role in the genesis of rheumatoid arthritis. It also appears that some subtypes of anti citrullinated peptide antibodies are preferentially present in the lungs.
The hypothesis behind our project is that one or more subtypes of anti citrullinated peptide antibodies with a preferential tropism for the lung would attack the parenchyma and pulmonary airways.
Currently, there are no data on interstitial pneumopathy in black and Afro-Caribbean subjects with rheumatoid arthritis.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with rheumatoid arthritis ACR/EULAR 2010
- •Patient with a higher age or equal to 18
- •Patient receiving social security
- •Patient giving his free and informed written consent
排除标准
- •Patient with overlap syndrome with another autoimmune disease
- •Patients with known severe cardiopulmonary pathology
- •Woman who is pregnant and breast feeding
- •Patient with language difficulties or understanding
结局指标
主要结局
Frequency of the positivity of the anti citrullinated peptide antibodies and subtype
时间窗: three years
Presence of one or more subtypes of anti citrullinated peptide antibodies in the serum of patients with interstitial pneumopathy associated with rheumatoid arthritis who would be absent
次要结局
- Genetic analysis of the main mutations(three years)