NCT04434963Unknown不适用
Safety and Feasibility of Reversible Induction Strategy Supported by HFNC Combined With Specific Anesthetic
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Successful rate of reversion
研究概览
简要总结
This study would explore the safety and feasibility of a reversible induction strategy for uncertain difficult airway. This reversible induction strategy would include high flow nasal canular oxygenation support, short-term effect anesthetic including Propofol and Remifentanil for sedation and analgesia and Sugammadex would be used for reverse the muscle relaxant.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •>18 years old,<65 years old
- •Signed informed consent
- •Undergoing selective operation （ time of operation is over two hours）
- •ASA classification I-II
- •Mallampati classification 3-4
- •suspicious difficult airway, but the anesthetists decide to try to rapid induction
排除标准
- •Patients with several dysfunctions of liver, kidney or heart)
- •Patients with a full stomach or have other risk factors of reflux aspiration
- •Any medicine was taken before surgery, which might enhance or mitigate the effects of muscle relaxant
- •Infection of the mouth or nose
- •Allergy history of any medicine which would be used in this study
- •Pregnant and lactating women
- •Patients with neuromuscular disease
结局指标
主要结局
Successful rate of reversion
时间窗: From the beginning of induction to 15min later
次要结局
- consciousness reversion time(From the beginning of induction to 15min later)
- Tidal volume 6-8ml tidal volume 6-8ml/kg reversion time(From the beginning of induction to 15min later)
- TOFr 0.9 reversion time(From the beginning of induction to 15min later)
- BIS 80 reversion time(From the beginning of induction to 15min later)
研究者
diansan su
Principal Investigator
RenJi Hospital
研究点 (1)
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