Treatment of couples with unexplained subfertility and an unfavourable prognosis: a randomised trial comparing the effectiveness of intrauterine insemination with ovarian hyperstimulation and in-vitro fertilisation with single embryo transfer

Academic Medical Center (AMC) (The Netherlands)0 个研究点目标入组 116 人开始时间: 2006年12月28日最近更新: 2021年1月25日

试验速览

•1. Female age between 18 and 36 years
•2. Couples must be diagnosed with unexplained subfertility, defined as normal semen (pre-wash total motile sperm count of at least 40 million), spontaneous ovulatory cycle and patent Fallopian tubes, or with mild male subfertility, defined as a post-wash total motile sperm count above three million
•3. The couple has poor fertility prospects as calculated by the validated model of Hunault. A poor fertility prospect is defined as a chance of spontaneous pregnancy below 30% within 12 months

•1. Polycystic ovary syndrome
•2. Endocrinopathological disease like: Cushing syndrome, adrenal hyperplasia, hyperprolactinemia, acromegaly, imminent ovarian failure, premature ovarian failure, hypothalamic amenorrhea, hypothyroidy, diabetes mellitus type I
•3. If not willing or able to sign the consent form

发起方

Academic Medical Center (AMC) (The Netherlands)