The Opioid-sparing Effect and Reduced PONV Using Propacetamol in PCA Among Patients With High Risk of PONV
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- Incidence of PONV
研究概览
简要总结
While Patient-controlled analgesia (PCA) has the advantage of effectively reducing the degree of postoperative pain, it can also affect the patient's outcome by several adverse effects such as postoperative nausea and vomiting (PONV). Especially for high risk group of patients for PONV, the ideal regimen for sufficient analgesia with minimal adverse effect needs to be sought. Propacetamol is known for its effective, rapid analgesia, opioid-sparing effect, and is used widely for post operative pain management. This study aims to see the opioid-sparing effect and the degree of PONV when propacetamol is added to PCA for high risk PONV patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients scheduled for either 1-2 level spine fusion or laminectomy
- •ASA (American Society of Anesthesiology) physical status 1 or 2
- •Non-smoking female patients, between the age 20 and 65
排除标准
- •Administration of any anti-emetic agents within 24 hours prior to surgery
- •Administration of any opioid agents within 7 days prior to surgery
- •Regular administration of any steroid agents
- •Drug or alcohol-abuser
- •Patients with bowel movement disorder, liver or renal impairment, insulin-dependent diabetes. Patients who are pregnant, illiterate, or foreign.
- •Patients administered to Intensive Care Unit after surgery
研究组 & 干预措施
Propacetamol
干预措施: Propacetamol (Drug)
PCA regimen
routine PCA drug
干预措施: PCA regimen (Drug)
结局指标
主要结局
Incidence of PONV
时间窗: from immediate postop to 24 hours after the surgery
Incidence of postoperative nausea, vomiting - Number of events
次要结局
未报告次要终点