Relationship of Occupational Heat Stress Endurance, Work, and Percentage of Body Fat in Middle Aged Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Core (Rectal) Temperature Change with Exercise Level and Increased Heat Load
研究概览
简要总结
Obesity is associated with many undesirable health effects and disease, and middle age is associated with increased risk for disease. Unfortunately, while others have looked at the effects of obesity, gender, and middle age, the combined effects of obesity and middle age on men's ability to do work in hot industrial environments have not been satisfactorily investigated.
This small study evaluates the heat tolerance of lean and obese middle aged men both while exercising and resting and the ways in which each compensate for and dissipate increasing environmental heat and heat generated by the body while exercising.
As obesity is a worldwide public health crisis and as populations in many industrialized nations age, it is important to understand the combined effects of obesity and middle age for men on their ability to safely work in hot environments. Such information will permit establishing and revising of safe work standards and inform public health outreach to the target population, itself.
详细描述
The present study was initially approved by and conducted at The Pennsylvania State University in 1972 for the senior author's (Rodger J McCormick) D.Ed. thesis in Biological Sciences; funding support was provided by the US National Institute of Arthritis, Metabolism, and Digestive Diseases Grant AM-08311 and National Institutes of Health Grant 01748. Data re-analysis and representation of that study was first approved in 2011 by and conducted at the FSRG deGruyter-McKusick Institute of Health Sciences for partial fulfillment of an MS in Clinical and Applied Physiology being pursued by the junior author (Mikaela I Poling). No funding was received for this use of existing data.
Importance of Present Study:
Several heat tolerance studies, including Kenny, Gagnon, Dorman, Hardcastle, and Joy (2010), have indicated that middle-age men can perform hard work in hot environments nearly as well as younger men. Dufour and Candas (2007), in comparing passive heat responses and sudomotor function in young, middle aged, and older men, found only local, not global, decreases in sweat gland output in the two older groups, suggesting at least some significant preservation of sudomotor function. Since most studies employed subjects with lean normal body types, their results in terms of physiological reactions to heat stress may not be applicable to obese middle aged men. Other studies have demonstrated degraded heat stress exercise capacity in obese persons.
Within high heat stress areas such as in the steel, fiberglass, aluminium, mining, professional sports, and defense industries, lean and obese middle aged men can readily be observed performing the same work task in the same hot environment. Little attention has been given to differences between the lean and obese middle aged men in their physiological responses to the combination of internal heat production from the work task performed and the heat load imposed from the external environment.
In the present study, occupational heat stress endurance differences between lean and obese middle aged men and effect of obesity are investigated under laboratory simulated conditions to test the following hypotheses: (1) with greater baseline cardiovascular demands, it is expected that obese middle aged men will have reduced environmental heat tolerance and will gain and store more total heat; (2) poorer environmental heat tolerance of obese middle aged men will be greatly magnified by work (producing added metabolic heat); (3) lean middle aged men will thermoregulate well; (4) lean middle aged men will show few, if any, major signs of inability to compensate for added cardiovascular demands; (5) obese middle aged men will be functioning at a higher percentage of their maximal ventilation of expired oxygen; and (6) obese middle aged men will have poorer pulmonary fitness, as measured by maximal ventilation of expired oxygen, than lean middle aged men.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Able and willing to give consent and to complete minimum study procedures, as defined by the protocol
- •Non-invasive resting blood pressure within normal limits
- •Resting electrocardiogram within normal limits
- •Hematology and Chemistry (blood) panels within normal limits
- •Urinalysis (pH, glucose, and protein) within normal limits
- •Negative cardiopulmonary stress test
- •Absence of acute or chronic metabolic, cardiovascular, pulmonary, and orthopedic disease
排除标准
- •Unable or unwilling to give consent or to complete minimum study procedures, as defined by the protocol
- •Non-invasive resting blood pressure outside normal limits
- •Resting electrocardiogram outside normal limits
- •Hematology and Chemistry (blood) panels outside normal limits
- •Urinalysis (pH, glucose, and protein) outside normal limits
- •Positive cardiopulmonary stress test
- •Presence of acute or chronic metabolic, cardiovascular, pulmonary, and orthopedic disease
结局指标
主要结局
Core (Rectal) Temperature Change with Exercise Level and Increased Heat Load
时间窗: Evaluated during each session at rest and while exercising, with sessions lasting approximately 165-170 min
Failure to maintain rectal temperature within 0.15° C of subject baseline for interval from end of exercise Bout 2 to Bout 3.
Oxygen Consumption Change with Exercise Level and Increased Heat Load
时间窗: Evaluated near the end of Exercise Bout 1 (2 min) and 3 (2 min)
Oxygen consumption, measured by ventilation of expired oxygen, is used as a measure of physiological strain imposed by metabolic needs during exercise and exaggerated by obesity.
Difference in Routine and Maximal Ventilation of Expired Oxygen at Neutral Ambient Temperature
时间窗: Cardiopulmonary Stress Test, during the last 1 min of warm-up and at end of progressive portion as volitional exhaustion approached
Warm-up approximates steady, normal work, while the progressive portion of the text places maximal metabolic burden on the subject in order to measure upper limit of heart and lung function
Heart rate Change with Exercise Level and Increased Heat Load
时间窗: Evaluated during each session at rest and while exercising, with sessions lasting approximately 165-170 min
Increased heart rate, measured electrocardiographically, is used as an index of cardiovascular strain imposed by needs during exercise and exaggerated by obesity.
次要结局
- Perceived Exertion Change with Exercise Level and Increased Heat Load(Evaluated during each session at rest and while exercising, with sessions lasting approximately 165-170 min)
- Non-Invasive Arterial Blood Pressure Change with Exercise Level and Increased Heat Load(Evaluated at rest before exercise (20-25 min) and at Rest I (5 min), II (5 min), and III (15 min))
- Heart Rhythm Change with Exercise Level and Increased Heat Load(Evaluated during each session at rest and while exercising, with sessions lasting approximately 165-170 min)
- Metabolic Rate Change with Exercise Level and Increased Heat Load(Evaluated near the end of Exercise Bout 1 (2 min) and Bout 3 (2 min).)
- Heat Load Change with Exercise Level and Increased Environmental Temperature(During Rest I (5 min), II (5 min), and III (15 min))