NCT00569621已完成2 期
A Randomized, Double-Masked, Placebo-Controlled Two Cross Over Study Comparing the Effects of Moxaverine and Placebo on Ocular Blood Flow
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Retinal and Choroidal Blood flow
研究概览
简要总结
It is known that several common eye diseases are associated with ocular perfusion abnormalities. Moxaverine is used in the therapy of perfusion abnormalities in the brain, the heart and the extremities because of its direct vasodilatory effects. The present study seeked to investigate whether moxaverine alters ocular blood flow in healthy volunteers after intravenous administration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •6 healthy volunteers of either sex
- •Age 18-35 yrs.
- •Body mass index between 15th and 85th percentile, nonsmokers
排除标准
- •Regular use of medication
- •Abuse of alcoholic beverages or drugs
- •Participation in a clinical trial in the 3 weeks preceding the study
- •Treatment in the previous 3 weeks with any drug
- •Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- •History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of study drugs
- •Blood donation during the previous 3 weeks
- •Ametropy less 3 dpt
- •Acute gastric bleeding, massive cerebral hemorrhage related to stroke
- •Women: pregnancy or lactation.
研究组 & 干预措施
1
Experimental
干预措施: Moxaverine (Drug)
2
Placebo Comparator
干预措施: physiological saline (Drug)
结局指标
主要结局
Retinal and Choroidal Blood flow
时间窗: 2 hours
次要结局
未报告次要终点
研究者
研究点 (1)
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