Risk Factors Related to Rupture Flow-related Aneurysms in Posterior Arteriovenious Malformation: A Muti-center Observentional Research.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- characteristics of flow-related aneurysm
研究概览
简要总结
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
- •No history of stroke, Marfan syndrome, polycystic kidney disease
排除标准
- •pAVM without flow-related aneurysms
- •Absence of clinical data
结局指标
主要结局
characteristics of flow-related aneurysm
时间窗: From enrollment to the end of treatment at 8 weeks
size ratio(aneurysm depth (mm)/parent artery diameter (mm))
次要结局
未报告次要终点
研究者
Lu Hua
professor
The First Affiliated Hospital with Nanjing Medical University
