Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 3
- 主要终点
- gene expression
研究概览
简要总结
For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.
详细描述
This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •consent form the study signed
- •consent form for genetic study signed
- •normal laboratory values for liver enzymes, glucose, lipid
- •Exclusion Criteria (common to the two groups):
- •vegetarian
- •heavy smoking
- •heavy alcohol
- •depressive
- •taking hypolipidemic or antihypertensive drugs
- •dyslipidemia
排除标准
- 未提供
结局指标
主要结局
gene expression
时间窗: After one month of lipid overnutrition
Level of genes (which regulate the lipid and energy metabolism) expression in fat and muscle tissues
次要结局
- Anthropometric parameter(After one month of lipid overnutrition)
- Autonomic nervous system activity(After one month of lipid overnutrition)
- gastrointestinal hormone level(After one month of lipid overnutrition)