Beyond Conventional MRI: Multi-Echo Fast Field Echo (mFFE) MRI for Cortical Bone Evaluation in Knee Osteoarthritis Compared With CT
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 80
- 主要终点
- Diagnostic accuracy of mFFE MRI for cortical bone changes
研究概览
简要总结
This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT.
详细描述
Knee osteoarthritis involves microstructural alterations in subchondral and cortical bone. Conventional MRI has limitations in visualizing cortical bone due to short T2 relaxation times. Multi-echo fast field echo (mFFE) sequences can produce CT-like images of cortical bone without ionizing radiation.
This observational study will include patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis. All participants will undergo both mFFE MRI and CT of the knee. The accuracy of mFFE MRI in detecting cortical bone degenerative changes will be compared with CT as the reference standard.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Age 40 years or older
- •Clinically suspected or confirmed knee osteoarthritis
- •Able and willing to provide informed consent
排除标准
- •- Implanted electronic devices (pacemakers, ICDs, neurostimulators, cochlear implants)
- •Metallic foreign bodies in the eyes or orbits
- •Ferromagnetic cerebral aneurysm clips
- •Implantable infusion pumps
- •Pregnancy
研究组 & 干预措施
Single cohort: Patients with knee osteoarthritis
Patients aged 40 years or older with knee osteoarthritis who will undergo both multi-echo fast field echo (mFFE) MRI and CT of the knee for comparison of cortical bone evaluation.
结局指标
主要结局
Diagnostic accuracy of mFFE MRI for cortical bone changes
时间窗: Baseline
Overall diagnostic accuracy percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard
次要结局
- Sensitivity of mFFE MRI for cortical bone changes(Baseline)
- Specificity of mFFE MRI for cortical bone changes(Baseline)
- Detection of subchondral sclerosis(Baseline)
- Detection of osteophytes(Baseline)
- Detection of joint space narrowing(Baseline)
- Image quality score(Baseline)
研究者
Fatima Mahmoud Hammad Eltony
Resident Physician
Assiut University