跳至主要内容
临床试验/CTRI/2025/07/090003
CTRI/2025/07/090003尚未招募Phase 3 4

Comparative Evaluation of the Antimicrobial Efficacy of Magnetized Water and Normal Saline against E. faecalis in Primary Teeth: An in vivo study.

Datta Meghe Institue of Higher Education and Research1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2025年7月25日最近更新:

试验速览

阶段
Phase 3 4
状态
尚未招募
发起方
入组人数
70
试验地点
1
主要终点
Magnetized water will have better efficacy against E. faecalis

研究概览

简要总结

Microorganisms play a crucial role in the development of pulpal and periapical infections, with Enterococcus faecalis (E. faecalis) being one of the most persistent pathogens found in root canal failures. Effective elimination of such microorganisms is essential for the success of endodontic therapy. Magnetized water, with its altered physicochemical properties, has recently emerged as a potential alternative root canal irrigant due to its increased alkalinity and reduced surface tension. This study aims to compare and evaluate the antimicrobial efficacy of magnetized water and normal saline against E. faecalis in primary teeth through an in vivo study. This will be in vivo study conducted on primary teeth indicated for pulpectomy in children. Pre- and post-irrigation microbial samples were collected from selected teeth and cultured on Brain Heart Infusion (BHI) agar to determine colony-forming units (CFUs) of E. faecalis. The teeth were randomly assigned to two groups: Group A (irrigated with magnetized water) and Group B (irrigated with normal saline). The reduction in microbial load was recorded and compared between the two groups.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
4.00 Year(s) 至 10.00 Year(s)(—)
性别
All

入选标准

  • Primary teeth with deep carious lesions indicated for pulpectomy.
  • Teeth with necrotic pulp.

排除标准

  • Children with systemic diseases or immunocompromised conditions.
  • Teeth with severe destruction not suitable for restoration.
  • Permanent teeth.
  • Primary teeth with periapical abscess.

结局指标

主要结局

Magnetized water will have better efficacy against E. faecalis

时间窗: Assessment will be done before starting the procedure and after completion of procedure

次要结局

未报告次要终点

研究者

发起方
Datta Meghe Institue of Higher Education and Research
申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Dr Ashray Nimje

Datta Meghe Institute of Higher Education and Research

研究点 (1)

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