A Multicenter, Observational Study to Evaluate Clinical Manifestation, Diagnosis and Treatment of Primary Hemifacial Spasm in Chinese Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,003
- 试验地点
- 1
- 主要终点
- The percentage of the treatment methods of HFS in outpatient subjects
研究概览
简要总结
To determine the clinical manifestation, diagnosis and treatment options of primary hemifacial spasm in Chinese outpatient subjects
详细描述
About 1000 outpatient subjects will be recruited. The inclusion criteria include clinically diagnosed primary hemifacial spasm, male or female 18 to 80 years old and informed consent has been obtained. The exclusion criteria include secondary hemifacial spasm, other involuntary facial movement disorder, history of surgery of microvascular decompression of the facial nerve and so on. The outcome measures include the percentage of the treatment methods of HFS in outpatient subjects, aggrevated and relieved factors of HFS symptom, concomitant symptoms of HFS and adverse events of botulinum toxin treatment in HFS patients.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1.Clinically diagnosed primary hemifacial spasm
- •Tonic and clonic contractions of muscles innervated by the unilateral facial nerve.
- •No other neurological disorder. 2.Male or female 18 to 80 years old 3.Informed consent has been obtained
排除标准
- •Secondary hemifacial spasm: brainstem tumor, surgery, facial neuritis and so on.
- •Other involuntary facial movement disorder: facial synkinesia after facial palsy, tics, myokymia and focal motor seizures.
- •History of surgery of microvascular decompression of the facial nerve.
- •Participation in another clinical study currently.
- •Not able to understand and answer questionnaire.
- •Investigator's opinion that the subject has a concurrent condition(s) that may confound the study results.
结局指标
主要结局
The percentage of the treatment methods of HFS in outpatient subjects
时间窗: November, 2012
次要结局
- Distribution of onset age of hemifacial spasm patients(November, 2012)
- Analysis of aggrevated and relieved factors of HFS symptom(November, 2012)
- Analysis of concomitant symptoms of hemifacial spasm(November, 2012)
- Adverse events of botulinum toxin treatment in hemifacial spasm(November, 2012)