NCT03156569已完成不适用
Oral Health and Salivary Markers in Patients With Xerostomia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Interleukins
研究概览
简要总结
The purpose of this study was to investigate the salivary levels of inflammatory and their association with oral health in xerostomía patient
详细描述
Primary Outcome Measures:
- salivary Proinflammatory and anti-inflammatory cytokines
- questionnaire is provided to the patient for xerostomia characterization
Secondary Outcome Measures:
- Probing pocket depth
- Probing pocket depth and clinical attachment level
- Gingival index
- Plaque index
- Bleeding on probing
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patient must have clinical symptoms of xerostomia (dry mouth)
排除标准
- •Head and neck radiotherapy
- •Administration anti-inflammatory drugs or antibiotic therapies within the previous 6 months
- •Patients who are unable or unwilling to cooperate
- •Patient suffering from cancer
结局指标
主要结局
Interleukins
时间窗: 2 months
Analytes in saliva IFN-(pg/ml), IL-10(pg/ml), IL-1b(pg/ml), IL-4 (pg/ml)and IL-6 (pg/ml)
saliva flow rate
时间窗: 2 months
Unstimulated salivary flow rate. Pathological \< or 1.5 ml/ 15 minutes.
Xerostomia
时间窗: 2 months
Visual Analogue Scale (VAS) for xerostomia severity (0 cm: no xerostomía , 10cm : very severe xerostomia ).
次要结局
- Oral Exam(4 months)
- Periodontal evaluation(4 months)
研究者
Pia Lopez Jornet
MD DDS PhD
Universidad de Murcia
研究点 (1)
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