NCT01965574已完成不适用
Evaluation of Performance Diagnosis of Hemodynamic Parameters of Preload Dependence in ARDS Patients During Prone Position
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 2
- 主要终点
- Area under ROC curve of the variation in continuous cardiac output during Trendelenburg position, to detect preload dependence
研究概览
简要总结
Preload dependence assessment is difficult during prone position, and to date, no hemodynamic parameters have been validated to rationalize fluid loading in that position. This study aims to validate several hemodynamic parameters, using continuous cardiac output by pulse contour analysis and transpulmonary thermodilution.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ARDS patient
- •mechanically ventilated in prone position
- •sedated and paralyzed
- •with continuous cardiac output monitoring by transpulmonary thermodilution and pulse contour analysis
- •fluid loading as indicated by attending physician
排除标准
- •Age below 18
- •no affiliation to social security
- •Vena cava obstruction
- •previous inclusion in protocol
结局指标
主要结局
Area under ROC curve of the variation in continuous cardiac output during Trendelenburg position, to detect preload dependence
时间窗: 1 minute after Trendelenburg position onset.
Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%
次要结局
- Area under ROC curve of the respiratory variation in pulse pressure to detect preload dependence(1 minute after tidal volume increase to 8 ml/kg)
- Area under ROC curve of the variation in continuous cardiac output during end-expiratory occlusion to detect preload dependence(15 seconds after the onset of end-expiratory occlusion)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Assessment of Preload Responsiveness in ARDS Patients During Prone PositionHemodynamic InstabilitySeptic ShockAcute Respiratory Distress SyndromeNCT04457739Bicetre Hospital58
终止
不适用
Assessment of Preload Dependency Via Measurement of Peripheral Venous Pressure During an Alveolar Recruitment ManoeuvreIntensive Care PatientsNCT05026255GCS Ramsay Santé pour l'Enseignement et la Recherche21
Unknown
不适用
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCOShockLow Cardiac OutputSepsisSystemic Inflammatory Response SyndromeDilated CardiomyopathyNCT01157299Hospital Universitario La Paz100
Unknown
不适用
Hemodynamic Forces at Rest and Stress vs. Adenosine and Dobutamine Stress Cardiac Magnetic ResonanceCoronary Artery DiseaseNCT04247698Assiut University112
已完成
不适用
Influence of Preload Dependence on the Effect of Phenylephrine on Cardiac OutputHypotensionNCT01730820University Hospital, Caen50