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临床试验/NCT05034081
NCT05034081已完成不适用

Impact Of Post-Bariatric Body Contouring Procedures on Patient Body Weight and Metabolism

Assiut University2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2021年9月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
60
试验地点
2
主要终点
Level of high sensitive CRP in blood

研究概览

简要总结

Is post-bariatric body contouring surgery prevent weight regain or no, and what is the effect on the patient's Metabolism? Few literature studies report body contouring surgery to be positively associated with maintained weight loss after obesity surgery but the measures of outcomes are diverse, and the collective magnitude of such an association is unknown.

The changes in gastrointestinal hormones, adipokines, and cytokines as well as in hypothalamic neuropeptides and neurotransmitters resemble the changes observed in the anorexia/cachexia, suggesting that bariatric surgery triggers a catabolic state responsible for loss of appetite and prolonged body weight reduction.

Weight regain after gastric bypass surgery occurs in about half of all patients within 2 years. About 50% of patients eventually gain a little weight back after hitting their low point. We need a more thorough evaluation to determine what factors - medical, psychological, lifestyle - are involved in the weight gain. One of the factors that seem to be responsible for the degree and durability of weight loss is post-bariatric body contouring procedures. However, metabolic consequences of removing excess subcutaneous adipose tissue by body contouring procedures have to a lesser extent been explored

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

年龄范围
20 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Post-bariatric (sleeve) patients will do body contouring surgery.
  • Post-bariatric patients has been stable within 5 kg for 3 months
  • Age between 20-60 years old.
  • patients use the determinant fixed diet.

排除标准

  • Age below 20 and above 60 years old.
  • Non-compliance with the fixed diet.
  • psychotic patients.
  • Female patients seeking pregnancy.
  • Endocrine causes of obesity.
  • Bariatric surgery other than sleeve.

结局指标

主要结局

Level of high sensitive CRP in blood

时间窗: 4 years

Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. hsCRP increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in blood level of hsCRp. The unit of hsCRP is mg/dl.

Level of Tumor necrotizing factor alfa in blood

时间窗: 4 years

Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. Tumor necrotizing factor alfa increase afer bariatric surgery and we want to know if its complete on increasing after body contouring surgeries or decresae . Tnf-a is measured by pg/ml

weight changes by kilograms

时间窗: 4 years

to know the effect of post-bariatric body contouring surgery in weight. Detect the weight cahnges of the patient every month afer body contouring surgery and body mass index also measured every month for six months

Level of BNP in blood

时间窗: 4 years

Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. BNP highly increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in the level of BNP. BNP unit is pg/ml

次要结局

  • Patient satisfaction score(4 years)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mohamed Shadad Rateb Mohamed

Assistant lecturer

Assiut University

研究点 (2)

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