NCT00356226已完成不适用
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.
CHU de Charleroi1 个研究点 分布在 1 个国家目标入组 64 人开始时间: 2000年10月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 64
- 试验地点
- 1
研究概览
简要总结
To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of diuretics) in cirrhotics with increased sympathetic nervous system. Secondary objectives were to study neuro-hormonal,hemodynamic effects and side effects of clonidine and diuretics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cirrhotic patients with ascites
- •Plasma norepinephrine level > 300 pg/mL (normal value: 185 - 275 pg/mL)
排除标准
- •Serum bilirubin concentration above 4.5 mg/dL
- •Prothrombin time below 40%
- •Platelet count below 40 X 10¨9/liter
- •Serum creatinine concentration above 2 mg/dL
- •Gastro-intestinal hemorrhage
- •Alcoholic hepatitis
- •Diabetes mellitus,
- •Hepatocellular carcinoma
- •Respiratory or cardiac failures
- •Hepatic encephalopathy
- •Bacterial infection
研究者
研究点 (1)
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