Interventional Study to Investigate the Effects of Percutaneous Closure of the Left Atrial Appendage on Atrial and Brain Natriuretic Peptide Secretion
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 主要终点
- Change from Baseline Plasma ANP and BNP levels after transcatheter closure of the left atrial appendage.
研究概览
简要总结
To date there are no data suggesting substantial effects of hormonal interaction after percutaneous closure of the left atrial appendage (LAA). Our hypothesis is that by excluding the LAA from blood flow physiologic stimuli for ANP and BNP produce may be impaired and consecutive release of the hormones may be reduced. Here, we present our experience of ANP and BNP secretion in the early postprocedural period after transcatheter closure of the LAA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •non-valvular atrial fibrillation
- •increased risk for thromboembolic complications (a minimum CHADS2Score of at least 2)
排除标准
- •Valvular-atrial fibrillation
- •Low risk for thromboembolic complications CHADS-2-Score < 2
结局指标
主要结局
Change from Baseline Plasma ANP and BNP levels after transcatheter closure of the left atrial appendage.
时间窗: participants will be followed for the duration of hospital stay, an expected average of 48 hours
Venous blood samples are taken before the procedure, immediately after implantation of the LAA closure device and on the first morning after the procedure. The blood is drawn into plastic tubes containing aprotinin and ethylenediaminetetraacetic acid disodium and is promptly centrifuged. The plasma obtained is stored at -20°C until assayed. The plasma BNP and ANP concentrations are then determined with a commercially available enzyme immunoassay kit (ELISA Kit for Brain Natriuretic Peptide, Uscn Life Science Inc., Missouri City, USA and ANP ELISA Kit, Hölzel Diagnostika, Köln, Germany).
次要结局
未报告次要终点
研究者
Nicolas Majunke
senior physician
University of Leipzig