Prenatal Emotion-Diet Interactions and the Metabolic Response
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Difference in the glycemic response to the standardized meal +/- psychosocial challenge task
研究概览
简要总结
This study seeks to understand how a mother's emotional state in pregnancy influences her biological response to food intake.
详细描述
The purpose of this research study is to understand how a mother's emotional state in pregnancy influences her biological response to food intake. Natural variation in emotional and mental state is frequently experienced in daily life, including during pregnancy. While the investigators understand that a healthy diet is important in pregnancy for maintaining blood sugar levels and other metabolic factors within normal ranges for optimal development of the baby, less consideration is given to the health effects of a mother's mental state during pregnancy. It may even be possible that, regardless of what a woman eats or drinks, the way her body responds to food may differ according to her emotional or mental state.
This research is particularly interested in understanding how the combination of maternal emotional state and diet influence metabolism in pregnancy. Thus, the aim of this study is to test whether and how an individual's emotional response to a mental challenge of varying complexity during pregnancy modifies the body's metabolic response to a standard breakfast.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age 18-40 years
- •Hispanic ethnicity
- •English and/or Spanish speaking
- •Multiparous
- •28-30 week's gestation
- •Pre-pregnancy BMI 25.0-34.9 kg/m2
- •Singleton, intrauterine pregnancy
- •Non-smoker
- •Non-diabetic and negative result on routine prenatal glucose challenge test (GCT)
排除标准
- •BMI <25.0 or ≥35.0 kg/m2
- •>30 week's gestation
- •multiple pregnancy
- •nulliparous
- •present/prior obstetric risk conditions (hypertension, preeclampsia, infections, placental abnormalities)
- •current smoker
- •current psychiatric disorders or undergoing treatment/taking psychiatric medications
- •Use of systemic/frequent corticosteroids or thyroid meds
- •Diabetic or presence of other metabolic or neuroendocrine disorders
研究组 & 干预措施
Psychosocial challenge task
Participants will be assigned to complete the Trier Social Stress Test (TSST) immediately after consuming a standardized breakfast drink
干预措施: Trier Social Stress Test (Behavioral)
Placebo challenge task
Participants will be assigned to complete the placebo non-stress task immediately after consuming a standardized breakfast drink
干预措施: Placebo Non-stress task (Behavioral)
结局指标
主要结局
Difference in the glycemic response to the standardized meal +/- psychosocial challenge task
时间窗: 2 hours
Glycemic response (area-under-the-curve of glucose) to the standardized breakfast drink following exposure to either the psychosocial challenge (TSST) or non-challenge (placebo-TSST) task.
次要结局
- Difference in the triglyceride response to the standardized meal +/- psychosocial challenge task(2 hours)
- Physiological stress response to the psychosocial challenge task(2 hours)
研究者
Karen Lindsay
Principal Investigator
University of California, Irvine