Undersøgelse af sammenhængen Mellem Biomekanik og Smerter Ved Gang
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Infrared marker XYZ coordinates
研究概览
简要总结
This interventional study aims to test gait biomechanics in healthy individuals with and without experimental knee pain. The main questions it aims to answer are:
- How do gait patterns change during painful walking?
- Can pain sensitivity testing and gait biomechanics predict experimental knee pain intensity?
Participants will receive two knee injections: a) Hypertonic saline (painful condition) and b) Isotonic saline (control condition).
详细描述
This study will be a randomized, crossover design where experimental knee pain will be provoked in healthy subjects using hypertonic saline injections to the infrapatellar fat pad (IFP). This will be controlled with a second injection of isotonic saline, which is non-painful. The participants will not be informed of the type of injection.
Hypertonic saline injections to the IFP usually provoke pain lasting about 15 minutes. Within this timeframe, motion capture will be conducted to estimate the biomechanics of gait. During the motion capture the participants will perform five 10-meter walking trials and three jumps. This process will be replicated for the control condition.
Additionally, the participants will have their pain sensitivity tested using cuff-pressure algometry before both IFP injections.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women aged 18-45 years
排除标准
- •Pregnancy
- •Drug addiction, defined as the use of cannabis, opioids, or other drugs
- •Previous or current neurologic or musculoskeletal illnesses
- •Current pain
- •Lack of ability to cooperate
研究组 & 干预措施
Painful condition
Hypertonic saline injection to the infrapatellar fat pad.
干预措施: Hypertonic saline injection (Other)
Control condition
Isotonic saline injection to the infrapatellar fat pad.
干预措施: Isotonic saline injection (Other)
结局指标
主要结局
Infrared marker XYZ coordinates
时间窗: Baseline
Marker-based motion capture with infrared cameras will be used to estimate placement of reflective markers in the XYZ planes measured in milimeters. Reflective markers will be placed from head-to-toe on anatomical landmarks.
Pain sensitivity.
时间窗: Baseline
Cuff-pressure algometry will be used to estimate pressure detection and tolerance thresholds, temporal summation of pain, and conditioned pain modulation.
次要结局
- Ground reaction forces(Baseline)
- Ground reaction moments(Baseline)
- The Pittsburgh Sleep Quality Index score(Baseline)
- The Pain catastrophizing Scale score(Baseline)
- The Hospital Anxiety and Depression Scale(Baseline)
- Knee symptoms(Baseline)
- Muscle activation(Baseline)
- Ground contact XZ location(Baseline)
研究者
Kristian Kjær Petersen
Principal Investigator
Aalborg University