Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative
研究概览
简要总结
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate choice self-administration procedures between drug and a non-drug alternative reinforcer presented during maintenance on d-amphetamine, which has been previously shown to reduce cocaine use.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Recent cocaine use, otherwise healthy
排除标准
- •Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease
研究组 & 干预措施
Active Treatment
Cocaine choice during d-amphetamine maintenance
干预措施: Cocaine (Drug)
Active Treatment
Cocaine choice during d-amphetamine maintenance
干预措施: Sustained Release d-Amphetamine (Drug)
Placebo Treatment
Cocaine choice during placebo maintenance
干预措施: Cocaine (Drug)
Placebo Treatment
Cocaine choice during placebo maintenance
干预措施: Sustained Release d-Amphetamine (Drug)
结局指标
主要结局
The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative
时间窗: 9 choice trials per cocaine dose level with each trial separated by 30 minutes
The reinforcing effects of cocaine were determined using a modified progressive ratio procedure (Lile et al., 2016) in which subjects made 9 choices between each available cocaine dose and money (US$6.00). Reinforcing effects are measured for each cocaine dose during both d-amphetamine and placebo maintenance.
次要结局
未报告次要终点
研究者
Joshua A. Lile, Ph.D.
Joshua A. Lile, Ph.D., Associate Professor of Behavioral Science
University of Kentucky