Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Expression of viral entry factors
研究概览
简要总结
The clinical presentation of the ongoing coronavirus disease-19 (COVID-19) pandemic in pregnant women is unique with more asymptomatic infection, higher morbidity when symptomatic, yet without a difference in mortality rate. This is strikingly different from the high mortality observed during the past influenza A pandemics. Though both influenza A virus (IAV) and SARS-CoV-2 are single-stranded RNA viruses, the exquisite vulnerability of pregnant women to influenza A but not COVID-19 remains a mystery. Our objective, therefore, is to determine the mechanisms that predispose pregnant women to severe influenza A but confer protection against SARS-CoV-2 infection by examining the viral entry factors and innate immune response mechanisms in the nasal epithelium of pregnant vs. non-pregnant age-matched women.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy, uncomplicated pregnant subjects in the third trimester ((≥ 28 ≤ 41 weeks' gestation)
- •Healthy non-pregnant adult female volunteers between the ages of 18 - 45 years.
- •Between 18-45 years old
- •Able to provide consent
排除标准
- •Patients in labor
- •Critically ill patients needing intubation and mechanical ventilation
- •Patients with fever or influenza-like illness
- •H/o epistaxis or rhinosinusitis
- •Nasal polyposis and deviated nasal septum
- •Preeclampsia and chronic hypertension
- •Use of anti-hypertensives
- •Ongoing seasonal allergy
- •H/o asthma
- •Recent recovery from SARS-CoV-2 or influenza A infection (≤ 4 weeks)
- •Recent receipt of either COVID-19 or influenza A vaccine (≤ 4 weeks)
- •Use of immunosuppressive medications
- •Use of inhaled corticosteroids
- •Use of hormonal contraceptives in non-pregnant population
- •Allergy to local anesthetic
结局指标
主要结局
Expression of viral entry factors
时间窗: Dec 2021
次要结局
- Expression of genes involved in innate immune response and host-pathogen interaction(Dec 2021)
研究者
Arvind Palanisamy
Associate Professor of Anesthesiology, Obstetrics and Gynecology
Washington University School of Medicine