NL-OMON37954已完成不适用
Assessment of microvascular alterations in patients with angina pectoris and no evidence of significant coronary artery disease - Glycocalyx perturbation in patients with microvascular angina pectoris
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 60 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Subjects who want to participate in the study should be over 18 years of age and be able to give informed consent.;Patients with coronary artery disease:
- •These patients should have proven coronary artery disease, defined as >=50% diameter stenosis objectified by coronary angiography. ;Patients with suspected small vessel disease:
- •These patients should have a positive exercise ECG but no evidence of significant coronary artery disease on their coronary angiogram. ;The time between the coronary angiogram and the MR perfusion scan and OPS imaging cannot exceed one year. It can be reasonably expected that the status of the coronaries will not have changed significantly over this time period if the symptoms of angina have not changed. ;Healthy controls:
- •These subjects must be free of angina pectoris or (a history of) coronary artery disease.
排除标准
- •Patients:;General:
- •- Age < 18 years.
- •- Unable to give informed consent.;Other cardiac pathology:
- •- Atrial fibrillation.
- •- Unstable angina pectoris (persistent CCS class IV despite medical treatment).
- •- Cardiogenic shock.
- •- Congestive heart failure NYHA class >=III. ;Contraindication to adenosine side effects:
- •- AV-block (2nd or 3rd degree).
- •- Severe asthma.
- •- COPD Gold IV.;General contra-indications to MR imaging
- •- Non compatible metallic implant (vascular clip, neuro-stimulator, cochlear implant).
- •- Pacemaker or ICD.
- •- Claustrophobia.
- •- Body weight >130 kg.
- •Contraindication to MRI contrast agent:
- •- Renal failure (GFR <= 30 mL/min) / chronic kidney disease stage 4 & 5. ;Healthy controls:;General:
- •- Age < 18 years.
- •- Unable to give informed consent.;Evidence of coronary artery disease:
- •- Angina pectoris.
- •- >=50% diameter coronary stenosis objectified by coronary angiography or computed tomographic (CT) angiography.
- •- Previous myocardial infarction.
- •- Previous coronary revascularization.
研究者
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