Effect of Remote Ischemic Post-Conditioning Vs Sham on Jugular Venous Oximetry and three-month neurological outcomes in patients Undergoing Intracranial Aneurysmal Clipping: A Randomized controlled trial.

This randomized controlled trial is aimed to study the effects of remote ischemic post-conditioning (RIC) versus a sham procedure on jugular venous oximetry and three-month neurological outcomes in patients undergoing intracranial aneurysmal clipping. Aneurysmal subarachnoid hemorrhage (aSAH), caused by ruptured intracranial aneurysms, is a significant global health issue with high morbidity and mortality rates. Cerebral vasospasm and delayed cerebral ischemia (DCI) are common complications of aSAH, contributing to poor outcomes.

Remote ischemic conditioning (RIC), which involves inducing brief periods of ischemia, has shown promise in reducing ischemia-reperfusion injury in various organs, including the brain. Previous studies have explored RIC in different contexts, such as pre-procedural RIC, early postconditioning, and chronic postconditioning, with some showing beneficial effects in cerebrovascular diseases and post-aneurysm repair surgery.

While RIC has been investigated for its potential to mitigate cerebral vasospasm and improve outcomes after aSAH, there is a lack of research on its impact on jugular venous oximetry during aneurysmal clipping procedures. This study aims to address this gap by evaluating whether RIC can improve cerebral oxygenation and neurological outcomes in this patient population, hypothesizing that RIC may protect against cerebral vasospasm and ischemic injury, leading to better cerebral oxygenation and improved neurological recovery.