Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 205
- 试验地点
- 2
- 主要终点
- Recurrence of AF
研究概览
简要总结
Because of the high recurrence rates following electrical cardioversion and high morbidity in AF patients there is a need to explore prediction models for AF recurrence following ECV. Previous studies have primarily focused on high-sensitivity CRP (hsCRP), CRP, and IL-6, while other inflammatory indexes and gene scores might hold greater value.
This prospective cohort study is planning to include 205 patients with persistent atrial fibrillation, planned for electrical cardioversion, and >18 years at two medium-sized hospitals in Sweden. Blood samples will be collected prior to electrical cardioversion and at 7-, 30-, 90-, and 180-days follow-up. Atrial fibrillation recurrence will be evaluated at follow-up or upon patient request and diagnosed with 12-lead ECG.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •persistent atrial fibrillation (ICD-10 I48.1), age over 18 years
排除标准
- •autoimmune diseases, inflammatory diseases, acute or chronic liver dysfunction, ongoing infectious diseases, thyroid disorders, or any other conditions known to impact inflammatory activity (including medication use and hematological diseases)
结局指标
主要结局
Recurrence of AF
时间窗: During follow-up (post ECV, day 7, 30, 90, and 180)
Recurrence of atrial fibrillation or atrial flutter recorded on 12-lead ECG or through pacemaker interpretation
次要结局
- Fluctuations of biomarkers and gene expression during follow-up(During follow-up (post ECV, day 7, 30, 90, and 180))
研究者
Jakob Hytting
MD
Vrinnevi Hospital