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临床试验/NCT07182136
NCT07182136已完成不适用

The Impact of Hepatic Steatosis on Survival After Pancreaticoduodenectomy for Resectable Pancreatic Cancer. A Multifactorial Analysis of Metabolic Dysfunction

Wei-Hsun Lu0 个研究点目标入组 200 人开始时间: 2015年1月1日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
200
主要终点
Incidence of postoperative nonalcoholic fatty liver disease (NAFLD)

研究概览

简要总结

We will use simple summaries, educational handouts, and discussions with doctors and nurses to explain this study. The study looks at patients with early-stage pancreatic cancer who undergo pancreaticoduodenectomy (Whipple surgery). We found that some patients develop fatty liver (non-alcoholic fatty liver disease, NAFLD) within six months after surgery, which can affect nutrition, blood sugar control, and long-term survival.

To help patients and families understand, we will:

  1. Provide clear written information sheets about the purpose of the study and its findings.
  2. Use diagrams or plain-language explanations of terms like "pancreatic exocrine function" and "fatty liver."
  3. Share results with healthcare providers so they can guide patients in nutrition, enzyme replacement, diabetes monitoring, and follow-up care.
  4. Offer contact information for the research team to answer questions.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Adults with stage I-II pancreatic ductal adenocarcinoma.
  • Underwent curative-intent pancreaticoduodenectomy (conventional or pylorus-preserving).
  • Surgery between January 2015 and May
  • Complete clinical and imaging data available.
  • Survived at least 6 months postoperatively.

排除标准

  • Preoperative hepatic steatosis
  • Incomplete clinical or imaging data
  • Death within 6 months after surgery

结局指标

主要结局

Incidence of postoperative nonalcoholic fatty liver disease (NAFLD)

时间窗: 6 months after pancreaticoduodenectomy

次要结局

未报告次要终点

研究者

发起方
Wei-Hsun Lu
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Wei-Hsun Lu

MD

National Cheng Kung University

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