Impact of Hydroxocobalamine on Outcome of Smoke Inhalation Injury Admitted to the ICU
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 739
- 试验地点
- 1
- 主要终点
- in ICU mortality
研究概览
简要总结
In Europe, hydroxocobalamin (cyanokit) has been used for suspicion of cyanide intoxication associated with the inhalation of fire smoke (1). However, the impact of hydroxocobalamin on outcome has never been thoroughly evaluated. While hydroxocobalamin has long been presented as being side-effect free, recent data suggest that in patients with severe burns, its use was associated with the occurrence of acute renal failure by intra tubular precipitation of oxalate crystals (2, 3). The purpose of this observational study is to investigate the association between use of hydroxocobalamin and outcome after smoke inhalation.
详细描述
In Europe, hydroxocobalamin (cyanokit) is the antidote recommended by expert consensus in cases of suspicion of cyanide intoxication associated with the inhalation of fire smoke (1). However, cyanokit has never been evaluated in this indication. Clinical data suggest that in patients with severe burns, its use is associated with the occurrence of acute kidney injury by intra tubular precipitation of oxalate crystals (2, 3). The purpose of this observational study is to investigate the association between use of hydroxocobalamin and outcome after smoke inhalation. The results of this study should guide future research and advice on the benefit-risk ratio of hydroxocobalamin.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admission in ICU with smoke inhalation diagnosed
排除标准
- 未提供
结局指标
主要结局
in ICU mortality
时间窗: through study completion, an average of 1 year
mortality in ICU or at day 90
次要结局
- in ICU acute kidney injury (based on the KDIGO definition)(through study completion, an average of 1 year)
研究者
Dr François Dépret
Chef de clinique assistant of the surgical critical burn unit, Principal investigator
Saint-Louis Hospital, Paris, France